Blog

4 Common Pain Relievers — and When to Use Them

What’s the best over-the-counter pain medication? It depends on what hurts — and why. 

“If you can target the pain with a medication that treats the underlying cause, the pain relief will be better,” says Sunny Linnebur, a professor at the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences in Aurora. 

Although your specific health conditions can alter the equation, here’s a general look at what’s best for what ails you.

1. Ibuprofen (Advil, Motrin, Midol), Naproxen (Aleve, Naprosyn, Naprelan)

What it is/What they are: Nonsteroidal anti-inflammatories (NSAIDs) that reduce fever and block prostaglandins, compounds that cause pain and inflammation

Best for: Headaches, musculoskeletal pain, arthritis, toothaches, backaches, sunburn. These are safer choices than aspirin for those with bleeding risks.

Don’t use for: Nerve pain

Avoid if: You take blood thinners or have uncontrolled high blood pressure, heart failure, or a history of ulcers or liver or kidney disease.

2. Acetaminophen (Tylenol, FeverAll, Panadol)

What it is/What they are: An analgesic and antifever medication that works in the brain to reduce mild to moderate pain by changing the way the body senses pain

Best for: Headaches, muscle aches, sore throat, toothaches, backaches, and sprains and strains. Best painkiller for people with GI issues

Don’t use for: Nerve pain or inflammatory conditions like arthritis

Avoid if: You are a heavy drinker. Take no more than 4,000 mg daily to avoid liver issues.

To learn about other common pain relievers and when to use them, from AARP, CLICK HERE.

Skip to content